Linking the FTO obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo

Variants in FTO have the strongest association with obesity; however, it is still unclear how those noncoding variants mechanistically affect whole-body physiology. We engineered a deletion of the rs1421085 conserved cis-regulatory module (CRM) in mice and confirmed in vivo that the CRM modulates Ir...

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Detalhes bibliográficos
Main Authors:	Laber, S, Forcisi, S, Bentley, L, Petzold, J, Moritz, F, Smirnov, KS, Al Sadat, L, Williamson, I, Strobel, S, Agnew, T, Sengupta, S, Nicol, T, Grallert, H, Heier, M, Honecker, J, Mianne, J, Teboul, L, Dumbell, R, Long, H, Simon, M, Lindgren, C, Bickmore, WA, Hauner, H, Schmitt-Kopplin, P, Claussnitzer, M, Cox, RD
Formato:	Journal article
Idioma:	English
Publicado em:	American Association for the Advancement of Science 2021

Linking the FTO obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo

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