Critical role of CD28/B7 costimulation in the development of human Th2 cytokine-producing cells.

CD28 is a major costimulatory signal receptor for T cells. We have used human naive CD4+ cells from cord blood to analyze the effect of the CD28/B7 costimulatory pathway on development of T helper (Th) subsets. We show that CD28 costimulation is critical for development of the Th2 cytokine-producing...

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Bibliographic Details
Main Authors: Webb, L, Feldmann, M
Format: Journal article
Language:English
Published: 1995