Critical role of CD28/B7 costimulation in the development of human Th2 cytokine-producing cells.
CD28 is a major costimulatory signal receptor for T cells. We have used human naive CD4+ cells from cord blood to analyze the effect of the CD28/B7 costimulatory pathway on development of T helper (Th) subsets. We show that CD28 costimulation is critical for development of the Th2 cytokine-producing...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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1995
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| _version_ | 1826301611124719616 |
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| author | Webb, L Feldmann, M |
| author_facet | Webb, L Feldmann, M |
| author_sort | Webb, L |
| collection | OXFORD |
| description | CD28 is a major costimulatory signal receptor for T cells. We have used human naive CD4+ cells from cord blood to analyze the effect of the CD28/B7 costimulatory pathway on development of T helper (Th) subsets. We show that CD28 costimulation is critical for development of the Th2 cytokine-producing cells and that in the absence of CD28 costimulation, cells are not primed to produce Th2 cytokines and consequently "default" to the Th1 subset, independent of the presence of exogenous cytokines. After CD28 costimulation, cells differentiate into a subset that produces Th2 cytokines. However, further CD28 costimulation is not required to maintain Th2 cytokine production. We conclude that D28 costimulation is critical for the development of Th0 and Th2 subsets, but not for the maintenance of cytokine production. |
| first_indexed | 2024-03-07T05:35:00Z |
| format | Journal article |
| id | oxford-uuid:e398b91d-fd90-4e2d-9aff-33c8383a830b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:35:00Z |
| publishDate | 1995 |
| record_format | dspace |
| spelling | oxford-uuid:e398b91d-fd90-4e2d-9aff-33c8383a830b2022-03-27T10:10:06ZCritical role of CD28/B7 costimulation in the development of human Th2 cytokine-producing cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e398b91d-fd90-4e2d-9aff-33c8383a830bEnglishSymplectic Elements at Oxford1995Webb, LFeldmann, MCD28 is a major costimulatory signal receptor for T cells. We have used human naive CD4+ cells from cord blood to analyze the effect of the CD28/B7 costimulatory pathway on development of T helper (Th) subsets. We show that CD28 costimulation is critical for development of the Th2 cytokine-producing cells and that in the absence of CD28 costimulation, cells are not primed to produce Th2 cytokines and consequently "default" to the Th1 subset, independent of the presence of exogenous cytokines. After CD28 costimulation, cells differentiate into a subset that produces Th2 cytokines. However, further CD28 costimulation is not required to maintain Th2 cytokine production. We conclude that D28 costimulation is critical for the development of Th0 and Th2 subsets, but not for the maintenance of cytokine production. |
| spellingShingle | Webb, L Feldmann, M Critical role of CD28/B7 costimulation in the development of human Th2 cytokine-producing cells. |
| title | Critical role of CD28/B7 costimulation in the development of human Th2 cytokine-producing cells. |
| title_full | Critical role of CD28/B7 costimulation in the development of human Th2 cytokine-producing cells. |
| title_fullStr | Critical role of CD28/B7 costimulation in the development of human Th2 cytokine-producing cells. |
| title_full_unstemmed | Critical role of CD28/B7 costimulation in the development of human Th2 cytokine-producing cells. |
| title_short | Critical role of CD28/B7 costimulation in the development of human Th2 cytokine-producing cells. |
| title_sort | critical role of cd28 b7 costimulation in the development of human th2 cytokine producing cells |
| work_keys_str_mv | AT webbl criticalroleofcd28b7costimulationinthedevelopmentofhumanth2cytokineproducingcells AT feldmannm criticalroleofcd28b7costimulationinthedevelopmentofhumanth2cytokineproducingcells |