Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity.

Folliculin (FLCN) is a tumor-suppressor protein mutated in the Birt-Hogg-Dubé (BHD) syndrome, which associates with two paralogous proteins, folliculin-interacting protein (FNIP)1 and FNIP2, forming a complex that interacts with the AMP-activated protein kinase (AMPK). Although it is clear that this...

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Bibliographic Details
Main Authors:	Siggs, O, Stockenhuber, A, Deobagkar-Lele, M, Bull, K, Crockford, T, Kingston, B, Crawford, G, Anzilotti, C, Steeples, V, Ghaffari, S, Czibik, G, Bellahcene, M, Watkins, H, Ashrafian, H, Davies, B, Woods, A, Carling, D, Yavari, A, Beutler, B, Cornall, R
Format:	Journal article
Language:	English
Published:	National Academy of Sciences 2016

Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity.

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