Timing the landmark events in the evolution of clear cell renal cell cancer: TRACERx Renal

Timing the landmark events in the evolution of clear cell renal cell cancer: TRACERx Renal

Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies across 33 patients with clear cell renal cell carcinoma. We find hotspots of point mutations in the 5&...

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Bibliographic Details
Main Authors: Mitchell, TJ, Turajlic, S, Rowan, A, Nicol, D, Farmery, JHR, O'Brien, T, Martincorena, I, Tarpey, P, Angelopoulos, N, Yates, LR, Butler, AP, Raine, K, Stewart, GD, Challacombe, B, Fernando, A, Lopez, JI, Hazell, S, Chandra, A, Chowdhury, S, Rudman, S, Soultati, A, Stamp, G, Fotiadis, N, Pickering, L, Au, L, Spain, L, Lynch, J, Stares, M, Teague, J, Maura, F, Wedge, DC, Horswell, S, Chambers, T, Litchfield, K, Xu, H, Stewart, A, Elaidi, R, Oudard, S, McGranahan, N, Csabai, I, Gore, M, Futreal, PA, Larkin, J, Lynch, AG, Szallasi, Z, Swanton, C, Campbell, PJ
Format: Journal article
Language:English
Published: Elsevier 2018

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