Design of a chemical probe for the bromodomain and plant homeodomain finger-containing (BRPF) family of proteins

Design of a chemical probe for the bromodomain and plant homeodomain finger-containing (BRPF) family of proteins

The bromodomain and plant homeodomain finger-containing (BRPF) family are scaffolding proteins important for the recruitment of histone acetyltransferases of the MYST family to chromatin. Here, we describe NI-57 (16) as new pan-BRPF chemical probe of the bromodomain (BRD) of the BRPFs. Inhibitor 16...

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Main Authors: Igoe, N, Bayle, E, Tallant, C, Fedorov, O, Meier, J, Savitsky, P, Rogers, C, Morias, Y, Scholze, S, Boyd, H, Cunoosamy, D, Andrews, D, Cheasty, A, Brennan, P, Müller, S, Knapp, S, Fish, P
格式: Journal article
语言:English
出版: American Chemical Society 2017

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