Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.

Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.

BACKGROUND: Complex etiology and pathogenesis of pathophysiological components of the cardio-metabolic syndrome have been demonstrated in humans and animal models. METHODOLOGY/PRINCIPAL FINDINGS: We have generated extensive physiological, genetic and genome-wide gene expression profiles in a congen...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Wallis, R, Collins, S, Kaisaki, P, Argoud, K, Wilder, S, Wallace, K, Ria, M, Ktorza, A, Rorsman, P, Bihoreau, M, Gauguier, D
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	Public Library of Science 2008

Παρόμοια τεκμήρια

Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.
ανά: Robert H Wallis, κ.ά.
Έκδοση: (2008-08-01)

Quantitative trait locus dissection in congenic strains of the Goto-Kakizaki rat identifies a region conserved with diabetes loci in human chromosome 1q.
ανά: Wallace, K, κ.ά.
Έκδοση: (2004)

Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto-Kakizaki rats.
ανά: Collins, S, κ.ά.
Έκδοση: (2006)

Enhanced insulin secretion and cholesterol metabolism in congenic strains of the spontaneously diabetic (Type 2) Goto Kakizaki rat are controlled by independent genetic loci in rat chromosome 8.
ανά: Wallis, R, κ.ά.
Έκδοση: (2004)

Comparative analysis of methods for gene transcription profiling data derived from different microarray technologies in rat and mouse models of diabetes.
ανά: Wilder, S, κ.ά.
Έκδοση: (2009)

Genetic control of plasma lipid levels in a cross derived from normoglycaemic Brown Norway and spontaneously diabetic Goto-Kakizaki rats.
ανά: Argoud, K, κ.ά.
Έκδοση: (2006)

Construction of congenic lines for the locus Nidd/gk1 controlling glucose tolerance in the GK rat.
ανά: Wallis, R, κ.ά.
Έκδοση: (1999)

Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene Expression.
ανά: Kaisaki, P, κ.ά.
Έκδοση: (2016)

Genomic organization of the rat Clock gene and sequence analysis in inbred rat strains.
ανά: Woon, P, κ.ά.
Έκδοση: (2006)

Integration of the rat recombination and EST maps in the rat genomic sequence and comparative mapping analysis with the mouse genome.
ανά: Wilder, S, κ.ά.
Έκδοση: (2004)

Integration of the rat recombination and EST maps in the rat genomic sequence and comparative mapping analysis with the mouse genome
ανά: Wilder, S, κ.ά.
Έκδοση: (2004)

Report on rat chromosome 4
ανά: Gauguier, D, κ.ά.
Έκδοση: (1999)

Comparative analysis of methods for gene transcription profiling data derived from different microarray technologies in rat and mouse models of diabetes
ανά: Bihoreau Marie-Thérèse, κ.ά.
Έκδοση: (2009-02-01)

Marker-assisted congenic screening (MACS): a database tool for the efficient production and characterization of congenic lines.
ανά: Collins, S, κ.ά.
Έκδοση: (2003)

QTL dissection using a GK.BN F2 cohort derived from a congenic line.
ανά: Collins, S, κ.ά.
Έκδοση: (2003)

Insulin secretion in adult rats after intrauterine exposure to mild hyperglycemia during late gestation.
ανά: Gauguier, D, κ.ά.
Έκδοση: (1991)

A gene map of the rat derived from linkage analysis and related regions in the mouse and human genomes.
ανά: Gauguier, D, κ.ά.
Έκδοση: (1999)

Genetic cartography of gene expression in white adipose tissue in the GK rat
ανά: Dubois, S, κ.ά.
Έκδοση: (2011)

Functional annotation of diabetic nephropathy genetic loci using kidney transcriptomic in diabetic rat models
ανά: Blancher, C, κ.ά.
Έκδοση: (2005)

Detailed comparative gene map of rat chromosome 1 with mouse and human genomes and physical mapping of an evolutionary chromosomal breakpoint.
ανά: Kaisaki, P, κ.ά.
Έκδοση: (2000)

LONG-TERM EFFECTS OF GESTATIONAL HYPERGLYCEMIA - A NON-GENETIC TRANSMISSION OF DIABETES IN THE RAT
ανά: Ktorza, A, κ.ά.
Έκδοση: (1988)

Inheritance of diabetes mellitus as consequence of gestational hyperglycemia in rats.
ανά: Gauguier, D, κ.ά.
Έκδοση: (1990)

Chromosomal mapping of quantitative trait loci controlling elastin content in rat aorta.
ανά: Gauguier, D, κ.ά.
Έκδοση: (2005)

[Possible contribution of hyperglycemia in utero to glucose homeostasis disorders in the adult]
ανά: Ktorza, A, κ.ά.
Έκδοση: (1997)

Functional annotations of diabetes nephropathy susceptibility loci through analysis of genome-wide renal gene expression in rat models of diabetes mellitus
ανά: Hu, Y, κ.ά.
Έκδοση: (2009)

Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models.
ανά: Dumas, M, κ.ά.
Έκδοση: (2007)

A high-resolution consensus linkage map of the rat, integrating radiation hybrid and genetic maps.
ανά: Bihoreau, M, κ.ά.
Έκδοση: (2001)

Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene Expression
ανά: Pamela J. Kaisaki, κ.ά.
Έκδοση: (2016-11-01)

Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes.
ανά: Woon, P, κ.ά.
Έκδοση: (2007)

Genetic control of differential acetylation in diabetic rats
ανά: Kaisaki, P, κ.ά.
Έκδοση: (2014)

Genetic dissection of a diabetes QTL in congenic lines of the GK rat and synteny conservation with diabetes susceptibility loci in human 1q.
ανά: Wallace, K, κ.ά.
Έκδοση: (2003)

Genome-wide sequencing and gene expression QTL mapping in the Goto-Kakizaki rat identify Ascl3 as a regulator of adipocyte function
ανά: Dubois, S, κ.ά.
Έκδοση: (2011)

Uncoupling proteins 2 and 3 (UCP2/3) map to a region linked to glucose intolerance and adiposity in the Goto-Kakizaki (GK) diabetic rat
ανά: Kaisaki, P, κ.ά.
Έκδοση: (1998)

Chromosomal mapping of quantitative trait loci controlling components of the aortic extracellular matrix in the Brown Norway rat
ανά: Behmoaras, J, κ.ά.
Έκδοση: (2004)

miRNA expression profile in rats correlates with type-2-diabetes phenotype
ανά: Herrera, B, κ.ά.
Έκδοση: (2008)

Medical Genetics: revenge of the thrift.
ανά: Kaisaki, P, κ.ά.
Έκδοση: (2005)

Multiple diabetes QTL on rat chromosome 1 defined by GK rat congenic lines
ανά: Collins, S, κ.ά.
Έκδοση: (2002)

Localization of tub and uncoupling proteins (Ucp) 2 and 3 to a region of rat chromosome 1 linked to glucose intolerance and adiposity in the Goto-Kakizaki (GK) type 2 diabetic rat.
ανά: Kaisaki, P, κ.ά.
Έκδοση: (1998)

Untargeted metabolome quantitative trait locus mapping associates variation in urine glycerate to mutant glycerate kinase
ανά: Cazier, J, κ.ά.
Έκδοση: (2012)

Untargeted metabolome quantitative trait locus mapping associates variation in urine glycerate to mutant glycerate kinase.
ανά: Cazier, J, κ.ά.
Έκδοση: (2012)