Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.

Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.

BACKGROUND: Complex etiology and pathogenesis of pathophysiological components of the cardio-metabolic syndrome have been demonstrated in humans and animal models. METHODOLOGY/PRINCIPAL FINDINGS: We have generated extensive physiological, genetic and genome-wide gene expression profiles in a congen...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Wallis, R, Collins, S, Kaisaki, P, Argoud, K, Wilder, S, Wallace, K, Ria, M, Ktorza, A, Rorsman, P, Bihoreau, M, Gauguier, D
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	Public Library of Science 2008

Ижил төстэй зүйлс

Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.
-н: Robert H Wallis, зэрэг
Хэвлэсэн: (2008-08-01)

Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto-Kakizaki rats.
-н: Collins, S, зэрэг
Хэвлэсэн: (2006)

Quantitative trait locus dissection in congenic strains of the Goto-Kakizaki rat identifies a region conserved with diabetes loci in human chromosome 1q.
-н: Wallace, K, зэрэг
Хэвлэсэн: (2004)

Enhanced insulin secretion and cholesterol metabolism in congenic strains of the spontaneously diabetic (Type 2) Goto Kakizaki rat are controlled by independent genetic loci in rat chromosome 8.
-н: Wallis, R, зэрэг
Хэвлэсэн: (2004)

Genetic control of plasma lipid levels in a cross derived from normoglycaemic Brown Norway and spontaneously diabetic Goto-Kakizaki rats.
-н: Argoud, K, зэрэг
Хэвлэсэн: (2006)

Comparative analysis of methods for gene transcription profiling data derived from different microarray technologies in rat and mouse models of diabetes.
-н: Wilder, S, зэрэг
Хэвлэсэн: (2009)

Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene Expression.
-н: Kaisaki, P, зэрэг
Хэвлэсэн: (2016)

Construction of congenic lines for the locus Nidd/gk1 controlling glucose tolerance in the GK rat.
-н: Wallis, R, зэрэг
Хэвлэсэн: (1999)

Genomic organization of the rat Clock gene and sequence analysis in inbred rat strains.
-н: Woon, P, зэрэг
Хэвлэсэн: (2006)

Integration of the rat recombination and EST maps in the rat genomic sequence and comparative mapping analysis with the mouse genome.
-н: Wilder, S, зэрэг
Хэвлэсэн: (2004)

Integration of the rat recombination and EST maps in the rat genomic sequence and comparative mapping analysis with the mouse genome
-н: Wilder, S, зэрэг
Хэвлэсэн: (2004)

Comparative analysis of methods for gene transcription profiling data derived from different microarray technologies in rat and mouse models of diabetes
-н: Bihoreau Marie-Thérèse, зэрэг
Хэвлэсэн: (2009-02-01)

Report on rat chromosome 4
-н: Gauguier, D, зэрэг
Хэвлэсэн: (1999)

Marker-assisted congenic screening (MACS): a database tool for the efficient production and characterization of congenic lines.
-н: Collins, S, зэрэг
Хэвлэсэн: (2003)

QTL dissection using a GK.BN F2 cohort derived from a congenic line.
-н: Collins, S, зэрэг
Хэвлэсэн: (2003)

Genetic cartography of gene expression in white adipose tissue in the GK rat
-н: Dubois, S, зэрэг
Хэвлэсэн: (2011)

Functional annotation of diabetic nephropathy genetic loci using kidney transcriptomic in diabetic rat models
-н: Blancher, C, зэрэг
Хэвлэсэн: (2005)

Insulin secretion in adult rats after intrauterine exposure to mild hyperglycemia during late gestation.
-н: Gauguier, D, зэрэг
Хэвлэсэн: (1991)

LONG-TERM EFFECTS OF GESTATIONAL HYPERGLYCEMIA - A NON-GENETIC TRANSMISSION OF DIABETES IN THE RAT
-н: Ktorza, A, зэрэг
Хэвлэсэн: (1988)

A gene map of the rat derived from linkage analysis and related regions in the mouse and human genomes.
-н: Gauguier, D, зэрэг
Хэвлэсэн: (1999)

Detailed comparative gene map of rat chromosome 1 with mouse and human genomes and physical mapping of an evolutionary chromosomal breakpoint.
-н: Kaisaki, P, зэрэг
Хэвлэсэн: (2000)

Inheritance of diabetes mellitus as consequence of gestational hyperglycemia in rats.
-н: Gauguier, D, зэрэг
Хэвлэсэн: (1990)

Chromosomal mapping of quantitative trait loci controlling elastin content in rat aorta.
-н: Gauguier, D, зэрэг
Хэвлэсэн: (2005)

A high-resolution consensus linkage map of the rat, integrating radiation hybrid and genetic maps.
-н: Bihoreau, M, зэрэг
Хэвлэсэн: (2001)

[Possible contribution of hyperglycemia in utero to glucose homeostasis disorders in the adult]
-н: Ktorza, A, зэрэг
Хэвлэсэн: (1997)

Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene Expression
-н: Pamela J. Kaisaki, зэрэг
Хэвлэсэн: (2016-11-01)

Functional annotations of diabetes nephropathy susceptibility loci through analysis of genome-wide renal gene expression in rat models of diabetes mellitus
-н: Hu, Y, зэрэг
Хэвлэсэн: (2009)

Genetic control of differential acetylation in diabetic rats
-н: Kaisaki, P, зэрэг
Хэвлэсэн: (2014)

Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models.
-н: Dumas, M, зэрэг
Хэвлэсэн: (2007)

Genetic dissection of a diabetes QTL in congenic lines of the GK rat and synteny conservation with diabetes susceptibility loci in human 1q.
-н: Wallace, K, зэрэг
Хэвлэсэн: (2003)

Medical Genetics: revenge of the thrift.
-н: Kaisaki, P, зэрэг
Хэвлэсэн: (2005)

Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes.
-н: Woon, P, зэрэг
Хэвлэсэн: (2007)

GENETIC DISSECTION ON NON-INSULIN-DEPENDENT DIABETES IN THE GOTO-KAKIZAKI (GK) RAT
-н: Gauguier, D, зэрэг
Хэвлэсэн: (1995)

Genome-wide sequencing and gene expression QTL mapping in the Goto-Kakizaki rat identify Ascl3 as a regulator of adipocyte function
-н: Dubois, S, зэрэг
Хэвлэсэн: (2011)

Uncoupling proteins 2 and 3 (UCP2/3) map to a region linked to glucose intolerance and adiposity in the Goto-Kakizaki (GK) diabetic rat
-н: Kaisaki, P, зэрэг
Хэвлэсэн: (1998)

Chromosomal mapping of quantitative trait loci controlling components of the aortic extracellular matrix in the Brown Norway rat
-н: Behmoaras, J, зэрэг
Хэвлэсэн: (2004)

miRNA expression profile in rats correlates with type-2-diabetes phenotype
-н: Herrera, B, зэрэг
Хэвлэсэн: (2008)

Multiple diabetes QTL on rat chromosome 1 defined by GK rat congenic lines
-н: Collins, S, зэрэг
Хэвлэсэн: (2002)

Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat.
-н: Gauguier, D, зэрэг
Хэвлэсэн: (1996)

Localization of tub and uncoupling proteins (Ucp) 2 and 3 to a region of rat chromosome 1 linked to glucose intolerance and adiposity in the Goto-Kakizaki (GK) type 2 diabetic rat.
-н: Kaisaki, P, зэрэг
Хэвлэсэн: (1998)