Structural basis of cholesterol binding by a novel clade of dendritic cell modulators from ticks
Two crystal structures of Japanin, an 18 kDa immune-modulatory lipocalin from the Brown Ear Tick (Rhipicephalus appendiculatus), have been determined at 2.2 and 2.4 Å resolution. In both crystal forms the protein is in complex with cholesterol, which sits in a closed pocket at the centre of the lipo...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Journal article |
| Published: |
Nature Publishing Group
2017
|