Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate.

Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate.

Inositol 1,4,5-trisphosphate (InsP3) receptors (InsP3Rs) are channels responsible for calcium release from the endoplasmic reticulum (ER). We show that the anti-apoptotic protein Bcl-2 (either wild type or selectively localized to the ER) significantly inhibited InsP3-mediated calcium release and el...

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Bibliographic Details
Main Authors: Chen, R, Valencia, I, Zhong, F, McColl, K, Roderick, H, Bootman, MD, Berridge, M, Conway, S, Holmes, AB, Mignery, G, Velez, P, Distelhorst, C
Format: Journal article
Language:English
Published: 2004

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