Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter Anion Exchanger 2 (SLC4A2)

Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter Anion Exchanger 2 (SLC4A2)

Acidic environments reduce the intracellular pH (pHi) of most cells to levels that are sub-optimal for growth and cellular functions. Yet, cancers maintain an alkaline cytoplasm despite low extracellular pH (pHe). Raised pHi is thought to be beneficial for tumor progression and invasiveness. However...

書誌詳細
主要な著者:	Michl, J, Monterisi, S, White, B, Blaszczak, W, Hulikova, A, Abdullayeva, G, Bridges, E, Yin, Z, Bodmer, W, Swietach, P
フォーマット:	Journal article
言語:	English
出版事項:	Cell Press 2023

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