Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter Anion Exchanger 2 (SLC4A2)

Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter Anion Exchanger 2 (SLC4A2)

Acidic environments reduce the intracellular pH (pHi) of most cells to levels that are sub-optimal for growth and cellular functions. Yet, cancers maintain an alkaline cytoplasm despite low extracellular pH (pHe). Raised pHi is thought to be beneficial for tumor progression and invasiveness. However...

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Bibliografische gegevens
Hoofdauteurs:	Michl, J, Monterisi, S, White, B, Blaszczak, W, Hulikova, A, Abdullayeva, G, Bridges, E, Yin, Z, Bodmer, W, Swietach, P
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	Cell Press 2023

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