Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter Anion Exchanger 2 (SLC4A2)
Acidic environments reduce the intracellular pH (pHi) of most cells to levels that are sub-optimal for growth and cellular functions. Yet, cancers maintain an alkaline cytoplasm despite low extracellular pH (pHe). Raised pHi is thought to be beneficial for tumor progression and invasiveness. However...
| 主要な著者: | , , , , , , , , , |
|---|---|
| フォーマット: | Journal article |
| 言語: | English |
| 出版事項: |
Cell Press
2023
|