Vaccinia virus proteins A52 and B14 Share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis.

Vaccinia virus proteins A52 and B14 Share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis.

Vaccinia virus (VACV), the prototype poxvirus, encodes numerous proteins that modulate the host response to infection. Two such proteins, B14 and A52, act inside infected cells to inhibit activation of NF-kappaB, thereby blocking the production of pro-inflammatory cytokines. We have solved the cryst...

Полное описание

Библиографические подробности
Главные авторы:	Graham, S, Bahar, M, Cooray, S, Chen, R, Whalen, D, Abrescia, N, Alderton, D, Owens, R, Stuart, D, Smith, G, Grimes, J
Формат:	Journal article
Язык:	English
Опубликовано:	Public Library of Science 2008

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