Insulin deficiency and insulin resistance interaction in diabetes: estimation of their relative contribution by feedback analysis from basal plasma insulin and glucose concentrations.
The liver and beta cells function in a negative feedback loop, which appears to have a predominant role in regulating both the basal plasma glucose and insulin concentrations. The degree of basal hyperglycemia in diabetes probably provides a bioassay of both the effect of a reduction in insulin secr...
Үндсэн зохиолчид: | Turner, R, Holman, R, Matthews, D, Hockaday, T, Peto, J |
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Формат: | Journal article |
Хэл сонгох: | English |
Хэвлэсэн: |
1979
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