Insulin deficiency and insulin resistance interaction in diabetes: estimation of their relative contribution by feedback analysis from basal plasma insulin and glucose concentrations.

Insulin deficiency and insulin resistance interaction in diabetes: estimation of their relative contribution by feedback analysis from basal plasma insulin and glucose concentrations.

The liver and beta cells function in a negative feedback loop, which appears to have a predominant role in regulating both the basal plasma glucose and insulin concentrations. The degree of basal hyperglycemia in diabetes probably provides a bioassay of both the effect of a reduction in insulin secr...

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Bibliografische gegevens
Hoofdauteurs:	Turner, R, Holman, R, Matthews, D, Hockaday, T, Peto, J
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	1979

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