Statistical challenges in the detection of mutation and variation using high throughput sequencing

The aim of this thesis is to obtain a better understanding of mutation rates within as well as between the genomes of humans and chimpanzees using data generated by high throughput sequencers. I will start with a review of the field and an overview of the technologies and protocols used to generate...

وصف كامل

التفاصيل البيبلوغرافية
المؤلف الرئيسي: Pfeifer, S
مؤلفون آخرون: McVean, G
التنسيق: أطروحة
اللغة:English
منشور في: 2012
الموضوعات: