Statistical challenges in the detection of mutation and variation using high throughput sequencing

The aim of this thesis is to obtain a better understanding of mutation rates within as well as between the genomes of humans and chimpanzees using data generated by high throughput sequencers. I will start with a review of the field and an overview of the technologies and protocols used to generate...

Полное описание

Библиографические подробности
Главный автор: Pfeifer, S
Другие авторы: McVean, G
Формат: Диссертация
Язык:English
Опубликовано: 2012
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