Interleukin-17A causes osteoarthritis-like transcriptional changes in human osteoarthritis-derived chondrocytes and synovial fibroblasts in vitro

Increased interleukin (IL)-17A has been identified in joints affected by osteoarthritis (OA), but it is unclear how IL-17A, and its family members IL-17AF and IL-17F, can contribute to human OA pathophysiology. Therefore, we aimed to evaluate the gene expression and signalling pathway activation eff...

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Bibliographic Details
Main Authors: Mimpen, JY, Baldwin, MJ, Cribbs, AP, Philpott, M, Carr, AJ, Dakin, SG, Snelling, SJB
Format: Journal article
Language:English
Published: Frontiers Media 2021