The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data

The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data

Background: Artesunate-amodiaquine (AS-AQ) is one of the most widely used artemisinin-based combination therapies (ACTs) to treat uncomplicated Plasmodium falciparum malaria in Africa. We investigated the impact of different dosing strategies on the efficacy of this combination for the treatment of...

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Main Authors: Adjuik, M, Allan, R, Anvikar, A, Ashley, E, Ba, MS, Barennes, H, Barnes, K, Bassat, Q, Baudin, E, Bjorkman, A, Bompart, F, Bonnet, M, Borrmann, S, Brasseur, P, Bukirwa, H, Checchi, F, Cot, M, Dahal, P, D'Alessandro, U, Deloron, P, Desai, M, Diap, G, Djimde, A, Dorsey, G, Doumbo, O, Espie, E, Etard, J, Fanello, C, Faucher, J, Faye, B, Flegg, J, Gaye, O, Gething, P, Gonzalez, R, Grandesso, F, Guerin, P, Guthmann, J, Hamour, S, Hasugian, A, Hay, S, Humphreys, G, Jullien, V, Juma, E, Kamya, MR, Karema, C, Kiechel, JR, Kremsner, P, Krishna, S, Lameyre, V, Ibrahim, L, Lee, S, Lell, B, Martensson, A, Massougbodji, A, Menan, H, Menard, D, Menendez, C, Meremikwu, M, Moreira, C, Nabasumba, C, Nambozi, M, Ndiaye, J, Nikiema, F, Nsanzabana, C, Ntoumi, F, Ogutu, B, Olliaro, P, Osorio, L, Ouedraogo, J, Penali, L, Pene, M, Pinoges, L, Piola, P, Price, R, Roper, C, Rosenthal, P, Rwagacondo, C, Same-Ekobo, A, Schramm, B, Seck, A, Sharma, B, Sibley, C, Sinou, V, Sirima, S, Smith, J, Smithuis, F, Some, F, Sow, D, Staedke, S, Stepniewska, K, Swarthout, T, Sylla, K, Talisuna, A, Tarning, J, Taylor, W, Temu, E, Thwing, J, Tjitra, E, Tine, R, Tinto, H, Vaillant, M, Valecha, N, Van den Broek, I, White, N, Yeka, A, Zongo, I, Resistance, W
Format: Journal article
Published: BioMed Central 2015

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