Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function

Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function

We determined the relationships between DNA sequence variation and DNA methylation using blood samples from 3,799 Europeans and 3,195 South Asians. We identify 11,165,559 SNP–CpG associations (methylation quantitative trait loci (meQTL), P less than 10−14), including 467,915 meQTL that operate in tr...

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Détails bibliographiques
Auteurs principaux: Hawe, JS, Wilson, R, Schmid, KT, Zhou, L, Lakshmanan, LN, Lehne, BC, Kühnel, B, Scott, WR, Wielscher, M, Yew, YW, Baumbach, C, Lee, DP, Marouli, E, Bernard, M, Pfeiffer, L, Matías-García, PR, Autio, MI, Bourgeois, S, Herder, C, Karhunen, V, Meitinger, T, Prokisch, H, Rathmann, W, Roden, M, Sebert, S, Shin, J, Strauch, K, Zhang, W, Tan, WLW, Hauck, SM, Merl-Pham, J, Grallert, H, Barbosa, EGV, MuTHER Consortium, Illig, T, Peters, A, Paus, T, Pausova, Z, Deloukas, P, Foo, RSY, Jarvelin, M-R, Kooner, JS, Loh, M, Heinig, M, Gieger, C, Waldenberger, M, Chambers, JC
Autres auteurs: Zondervan, KT
Format: Journal article
Langue:English
Publié: Springer Nature 2022

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