Huge (14-, 21-, 28-, 35-, 56- and 70-membered ring) macrocyclic lactams - a novel family of carbopeptoid-cyclodextrins

Hydrogenation of linear ω-azido-pentafluorophenyl esters gives cyclic peptides containing 14-, 21-, 28-, 35-, 56- and 70-membered ring lactams from oligomers derived from ε-amino acids in excellent to moderate yields with a lack of racemisation during the cyclisation step. © 2003 Elsevier Ltd. All r...

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Bibliographic Details
Main Authors: Mayes, B, Simon, L, Watkin, D, Ansell, C, Fleet, G
Format: Journal article
Language:English
Published: 2004