Review article: the therapeutic potential of 5-HT3 receptor antagonists in the treatment of irritable bowel syndrome.
There is evidence from studies, in both animals and humans, that 5-HT3 receptor blockade has potential value in the treatment of irritable bowel syndrome, particularly in those patients with diarrhoea-predominant bowel habits. New findings suggest that 5-HT3 receptors exist on gut afferent neurones...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Blackwell Publishing Ltd.
1999
|
| _version_ | 1826301905088806912 |
|---|---|
| author | Humphrey, P Bountra, C Clayton, N Kozlowski, K |
| author_facet | Humphrey, P Bountra, C Clayton, N Kozlowski, K |
| author_sort | Humphrey, P |
| collection | OXFORD |
| description | There is evidence from studies, in both animals and humans, that 5-HT3 receptor blockade has potential value in the treatment of irritable bowel syndrome, particularly in those patients with diarrhoea-predominant bowel habits. New findings suggest that 5-HT3 receptors exist on gut afferent neurones and that their activation by locally released 5-HT leads to visceral nociceptive stimulation, in addition to increased neuronally-mediated motor and secretory activity. If this concept is validated, it will provide a rationale for the use of 5-HT3 receptor antagonists in patients with increased gut motility, reduced fluid absorption and low nociceptive thresholds leading to abdominal pain. Alosetron is a highly selective, potent 5-HT3 receptor antagonist which is well absorbed with a long pharmacodynamic half-life. Its ability to provide long-lasting blockade of 5-HT3 receptors throughout the body make it an ideal candidate within its class to evaluate the clinical hypothesis that sustained and ubiquitous 5-HT3 receptor blockade is of value in the treatment of IBS. |
| first_indexed | 2024-03-07T05:39:28Z |
| format | Journal article |
| id | oxford-uuid:e50fb3b0-8a11-496e-b7b5-28f12c64295d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:39:28Z |
| publishDate | 1999 |
| publisher | Blackwell Publishing Ltd. |
| record_format | dspace |
| spelling | oxford-uuid:e50fb3b0-8a11-496e-b7b5-28f12c64295d2022-03-27T10:21:15ZReview article: the therapeutic potential of 5-HT3 receptor antagonists in the treatment of irritable bowel syndrome.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e50fb3b0-8a11-496e-b7b5-28f12c64295dEnglishSymplectic Elements at OxfordBlackwell Publishing Ltd.1999Humphrey, PBountra, CClayton, NKozlowski, KThere is evidence from studies, in both animals and humans, that 5-HT3 receptor blockade has potential value in the treatment of irritable bowel syndrome, particularly in those patients with diarrhoea-predominant bowel habits. New findings suggest that 5-HT3 receptors exist on gut afferent neurones and that their activation by locally released 5-HT leads to visceral nociceptive stimulation, in addition to increased neuronally-mediated motor and secretory activity. If this concept is validated, it will provide a rationale for the use of 5-HT3 receptor antagonists in patients with increased gut motility, reduced fluid absorption and low nociceptive thresholds leading to abdominal pain. Alosetron is a highly selective, potent 5-HT3 receptor antagonist which is well absorbed with a long pharmacodynamic half-life. Its ability to provide long-lasting blockade of 5-HT3 receptors throughout the body make it an ideal candidate within its class to evaluate the clinical hypothesis that sustained and ubiquitous 5-HT3 receptor blockade is of value in the treatment of IBS. |
| spellingShingle | Humphrey, P Bountra, C Clayton, N Kozlowski, K Review article: the therapeutic potential of 5-HT3 receptor antagonists in the treatment of irritable bowel syndrome. |
| title | Review article: the therapeutic potential of 5-HT3 receptor antagonists in the treatment of irritable bowel syndrome. |
| title_full | Review article: the therapeutic potential of 5-HT3 receptor antagonists in the treatment of irritable bowel syndrome. |
| title_fullStr | Review article: the therapeutic potential of 5-HT3 receptor antagonists in the treatment of irritable bowel syndrome. |
| title_full_unstemmed | Review article: the therapeutic potential of 5-HT3 receptor antagonists in the treatment of irritable bowel syndrome. |
| title_short | Review article: the therapeutic potential of 5-HT3 receptor antagonists in the treatment of irritable bowel syndrome. |
| title_sort | review article the therapeutic potential of 5 ht3 receptor antagonists in the treatment of irritable bowel syndrome |
| work_keys_str_mv | AT humphreyp reviewarticlethetherapeuticpotentialof5ht3receptorantagonistsinthetreatmentofirritablebowelsyndrome AT bountrac reviewarticlethetherapeuticpotentialof5ht3receptorantagonistsinthetreatmentofirritablebowelsyndrome AT claytonn reviewarticlethetherapeuticpotentialof5ht3receptorantagonistsinthetreatmentofirritablebowelsyndrome AT kozlowskik reviewarticlethetherapeuticpotentialof5ht3receptorantagonistsinthetreatmentofirritablebowelsyndrome |