Early antiretroviral therapy reduces hiv dna following perinatal HIV infection

Early antiretroviral therapy reduces hiv dna following perinatal HIV infection

: The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterised in perinatally acquired infection (PaHIV). In a prospective observational study of 20 children with PaHIV and sustained viral suppression...

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Bibliografische gegevens
Hoofdauteurs: Foster, C, Pace, M, Kaye, S, Hopkins, E, Jones, M, Robinson, N, Fidler, S, Frater, J, CHERUB Investigators
Formaat: Journal article
Taal:English
Gepubliceerd in: Lippincott, Williams & Wilkins 2017
Omschrijving
Samenvatting:: The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterised in perinatally acquired infection (PaHIV). In a prospective observational study of 20 children with PaHIV and sustained viral suppression on ART for >5 years, proviral DNA was significantly higher in deferred (>4 years) versus early (first year of life) ART recipients (p = 0.0062), and correlated with age of initiation (p = 0.13; r = 0.57). No difference was seen in cell-associated viral RNA (p = 0.36). Identifying paediatric populations with smaller reservoirs may inform strategies with potential to induce ART-free remission.

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