Neuronal accumulation of poly(ADP-ribose) after brain ischaemia.
Animal and in vitro studies suggest that overactivation of poly(ADP-ribose) polymerase (PARP) in response to oxidative DNA damage makes a substantial contribution to cell death after brain ischaemia. We have recently shown that global brain ischaemia due to cardiac arrest in man induces a rapid incr...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1999
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