In vivo imaging of MMP‐13 activity using a specific polymer‐FRET peptide conjugate detects early osteoarthritis and inhibitor efficacy
Imaging early molecular changes in osteoarthritic (OA) joints is instrumental for the development of disease‐modifying drugs. To this end, a fluorescent resonance energy transfer‐based peptide probe that is cleavable by matrix metalloproteinase 13 (MMP‐13) has been developed. This protease degrades...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal article |
| Published: |
Wiley
2018
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