In vivo imaging of MMP‐13 activity using a specific polymer‐FRET peptide conjugate detects early osteoarthritis and inhibitor efficacy

In vivo imaging of MMP‐13 activity using a specific polymer‐FRET peptide conjugate detects early osteoarthritis and inhibitor efficacy

Imaging early molecular changes in osteoarthritic (OA) joints is instrumental for the development of disease‐modifying drugs. To this end, a fluorescent resonance energy transfer‐based peptide probe that is cleavable by matrix metalloproteinase 13 (MMP‐13) has been developed. This protease degrades...

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Үндсэн зохиолчид: Duro‐Castano, A, Lim, N, Tranchant, I, Amoura, M, Beau, F, Wieland, H, Kingler, O, Herrmann, M, Nazaré, M, Plettenburg, O, Dive, V, Vicent, M, Nagase, H
Формат: Journal article
Хэвлэсэн: Wiley 2018

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