STAT3-mediated astrocyte reactivity associated with brain metastasis contributes to neurovascular dysfunction

Astrocytes are thought to play a pivotal role in coupling neural activity and cerebral blood flow. However, it has been shown that astrocytes undergo morphological changes in response to brain metastasis, switching to a reactive phenotype which has the potential to significantly compromise cerebrova...

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Bibliographic Details
Main Authors: Sarmiento Soto, M, Larkin, JR, Martin, C, Khrapitchev, AA, Maczka, M, Economopoulos, V, Scott, H, Escartin, C, Bonvento, G, Serres, S, Sibson, NR
Format: Journal article
Language:English
Published: American Association for Cancer Research 2020