Structure of the human RECQ1 helicase reveals a putative strand-separation pin.

RecQ-like helicases, which include 5 members in the human genome, are important in maintaining genome integrity. We present a crystal structure of a truncated form of the human RECQ1 protein with Mg-ADP. The truncated protein is active in DNA fork unwinding but lacks other activities of the full-len...

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Main Authors:	Pike, A, Shrestha, B, Popuri, V, Burgess-Brown, N, Muzzolini, L, Costantini, S, Vindigni, A, Gileadi, O
格式:	Journal article
语言:	English
出版:	2009
主题:	Mutant Proteins Kinetics Protein Binding DNA Escherichia coli Sequence Alignment Adenosine Diphosphate Protein Structure, Tertiary Amino Acid Motifs Zinc Adenosine Triphosphate Conserved Sequence Amino Acid Sequence enzymology metabolism Molecular Sequence Data RecQ Helicases chemistry

Structure of the human RECQ1 helicase reveals a putative strand-separation pin.

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