Restricted diffusion of a freely diffusible second messenger: Mechanisms underlying compartmentalized cAMP signalling
It is becoming increasingly evident that the freely diffusible second messenger cAMP can transduce specific responses by localized signalling. The machinery that underpins compartmentalized cAMP signalling is only now becoming appreciated. Adenylate cyclases, the enzymes that synthesize cAMP, are lo...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Published: |
2006
|
| _version_ | 1797100673469251584 |
|---|---|
| author | Zaccolo, M Di Benedetto, G Lissandron, V Mancuso, L Terrin, A Zamparo, I |
| author_facet | Zaccolo, M Di Benedetto, G Lissandron, V Mancuso, L Terrin, A Zamparo, I |
| author_sort | Zaccolo, M |
| collection | OXFORD |
| description | It is becoming increasingly evident that the freely diffusible second messenger cAMP can transduce specific responses by localized signalling. The machinery that underpins compartmentalized cAMP signalling is only now becoming appreciated. Adenylate cyclases, the enzymes that synthesize cAMP, are localized at discrete parts of the plasma membrane, and phosphodiesterases, the enzymes that degrade cAMP, can be targeted to selected subcellular compartments. A-kinase-anchoring proteins then serve to anchor PKA (protein kinase A) close to specific targets, resulting in selective activation. The specific activation of such individual subsets of PKA requires that cAMP is made available in discrete compartments. In this presentation, the molecular and structural mechanisms responsible for compartmentalized PKA signalling and restricted diffusion of cAMP will be discussed. ©2006 Biochemical Society. |
| first_indexed | 2024-03-07T05:40:56Z |
| format | Journal article |
| id | oxford-uuid:e58861fe-53f3-43e6-ba75-c47bb06b45b5 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T05:40:56Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:e58861fe-53f3-43e6-ba75-c47bb06b45b52022-03-27T10:24:45ZRestricted diffusion of a freely diffusible second messenger: Mechanisms underlying compartmentalized cAMP signallingJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e58861fe-53f3-43e6-ba75-c47bb06b45b5Symplectic Elements at Oxford2006Zaccolo, MDi Benedetto, GLissandron, VMancuso, LTerrin, AZamparo, IIt is becoming increasingly evident that the freely diffusible second messenger cAMP can transduce specific responses by localized signalling. The machinery that underpins compartmentalized cAMP signalling is only now becoming appreciated. Adenylate cyclases, the enzymes that synthesize cAMP, are localized at discrete parts of the plasma membrane, and phosphodiesterases, the enzymes that degrade cAMP, can be targeted to selected subcellular compartments. A-kinase-anchoring proteins then serve to anchor PKA (protein kinase A) close to specific targets, resulting in selective activation. The specific activation of such individual subsets of PKA requires that cAMP is made available in discrete compartments. In this presentation, the molecular and structural mechanisms responsible for compartmentalized PKA signalling and restricted diffusion of cAMP will be discussed. ©2006 Biochemical Society. |
| spellingShingle | Zaccolo, M Di Benedetto, G Lissandron, V Mancuso, L Terrin, A Zamparo, I Restricted diffusion of a freely diffusible second messenger: Mechanisms underlying compartmentalized cAMP signalling |
| title | Restricted diffusion of a freely diffusible second messenger: Mechanisms underlying compartmentalized cAMP signalling |
| title_full | Restricted diffusion of a freely diffusible second messenger: Mechanisms underlying compartmentalized cAMP signalling |
| title_fullStr | Restricted diffusion of a freely diffusible second messenger: Mechanisms underlying compartmentalized cAMP signalling |
| title_full_unstemmed | Restricted diffusion of a freely diffusible second messenger: Mechanisms underlying compartmentalized cAMP signalling |
| title_short | Restricted diffusion of a freely diffusible second messenger: Mechanisms underlying compartmentalized cAMP signalling |
| title_sort | restricted diffusion of a freely diffusible second messenger mechanisms underlying compartmentalized camp signalling |
| work_keys_str_mv | AT zaccolom restricteddiffusionofafreelydiffusiblesecondmessengermechanismsunderlyingcompartmentalizedcampsignalling AT dibenedettog restricteddiffusionofafreelydiffusiblesecondmessengermechanismsunderlyingcompartmentalizedcampsignalling AT lissandronv restricteddiffusionofafreelydiffusiblesecondmessengermechanismsunderlyingcompartmentalizedcampsignalling AT mancusol restricteddiffusionofafreelydiffusiblesecondmessengermechanismsunderlyingcompartmentalizedcampsignalling AT terrina restricteddiffusionofafreelydiffusiblesecondmessengermechanismsunderlyingcompartmentalizedcampsignalling AT zamparoi restricteddiffusionofafreelydiffusiblesecondmessengermechanismsunderlyingcompartmentalizedcampsignalling |