Additional Acetylcholine (ACh) Binding Site at alpha 4/alpha 4 Interface of (alpha 4 beta 2)(2)alpha 4 Nicotinic Receptor Influences Agonist Sensitivity
Nicotinic acetylcholine receptor (nAChR) α4 and β2 subunits assemble in two alternate stoichiometries to produce (α4β2) 2α4 and (α4β2) 2β2, which display different agonist sensitivities. Functionally relevant agonist binding sites are thought to be located at α4(+)/β2(-) subunit interfaces, but beca...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2011
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