Signalling hypoxia by HIF hydroxylases.

Signalling hypoxia by HIF hydroxylases.

Analysis of oxygen sensitive pathways that regulate the hypoxia inducible factor (HIF) transcriptional system has revealed a novel role for oxygenases in signalling hypoxia. The enzymes, which catalyse hydroxylation of specific prolyl and asparaginyl residues in the regulatory HIF-alpha subunits, be...

Полное описание

Библиографические подробности
Главные авторы:	Schofield, C, Ratcliffe, P
Формат:	Journal article
Язык:	English
Опубликовано:	2005

Схожие документы

Oxygen sensing by HIF hydroxylases.
по: Schofield, C, и др.
Опубликовано: (2004)

Inhibition of hypoxia inducible factor (HIF) hydroxylases
по: Conejo-Garcia, A, и др.
Опубликовано: (2005)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
по: Chan, M, и др.
Опубликовано: (2016)

Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing.
по: Webb, J, и др.
Опубликовано: (2009)

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
по: Hewitson, K, и др.
Опубликовано: (2002)

The HIF hydroxylase pathway and the tumour microenvironment
по: Ratcliffe, P
Опубликовано: (2008)

Regulation of HIF: prolyl hydroxylases.
по: Stolze, I, и др.
Опубликовано: (2006)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
по: Chowdhury, R, и др.
Опубликовано: (2013)

From erythropoietin to oxygen: hypoxia-inducible factor hydroxylases and the hypoxia signal pathway.
по: Ratcliffe, P
Опубликовано: (2002)

Pharmacological targeting of the HIF hydroxylases - A new field in medicine development.
по: Chan, M, и др.
Опубликовано: (2016)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
по: Mole, D, и др.
Опубликовано: (2003)

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).
по: Cockman, M, и др.
Опубликовано: (2006)

The use of dioxygen by HIF prolyl hydroxylase (PHD1).
по: McNeill, L, и др.
Опубликовано: (2002)

Therapeutic manipulation of the HIF hydroxylases.
по: Nagel, S, и др.
Опубликовано: (2010)

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
по: Flashman, E, и др.
Опубликовано: (2010)

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
по: Hewitson, K, и др.
Опубликовано: (2007)

Inhibition studies on hypoxia-inducible factor (HIF) hydroxylases
по: Chan, M
Опубликовано: (2014)

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
по: Schlemminger, I, и др.
Опубликовано: (2003)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
по: Cockman, M, и др.
Опубликовано: (2019)

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.
по: Willam, C, и др.
Опубликовано: (2006)

Studies on the inhibition of human hypoxia inducible factor (HIF) hydroxylases
по: Yeoh, KK
Опубликовано: (2012)

Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?
по: Moritz J. Strowitzki, и др.
Опубликовано: (2019-04-01)

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.
по: Kaelin, W, и др.
Опубликовано: (2008)

HIF-1 and HIF-2: working alone or together in hypoxia?
по: Ratcliffe, P
Опубликовано: (2007)

Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model
по: Maria Savyuk, и др.
Опубликовано: (2020-07-01)

Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases.
по: Lienard, B, и др.
Опубликовано: (2008)

Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors.
по: Tian, Y, и др.
Опубликовано: (2011)

Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
по: Tuckerman, JR, и др.
Опубликовано: (2004)

Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model
по: Singh, A, и др.
Опубликовано: (2020)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
по: Chowdhury, R, и др.
Опубликовано: (2016)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
по: Matthew E Cockman, и др.
Опубликовано: (2019-09-01)

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity.
по: Masson, N, и др.
Опубликовано: (2012)

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity
по: Masson, N, и др.
Опубликовано: (2012)

Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].
по: Stolze, I, и др.
Опубликовано: (2004)

Biochemistry of the hypoxia-inducible factor hydroxylases
по: Fiorini, G, и др.
Опубликовано: (2024)

Studies on HIF hydroxylases
по: Webb, J
Опубликовано: (2008)

Regulation of angiogenesis by hypoxia: role of the HIF system.
по: Pugh, C, и др.
Опубликовано: (2003)

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.
по: Masson, N, и др.
Опубликовано: (2003)

Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
по: Lippl, K
Опубликовано: (2018)

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay.
по: Ehrismann, D, и др.
Опубликовано: (2007)