Signalling hypoxia by HIF hydroxylases.

Analysis of oxygen sensitive pathways that regulate the hypoxia inducible factor (HIF) transcriptional system has revealed a novel role for oxygenases in signalling hypoxia. The enzymes, which catalyse hydroxylation of specific prolyl and asparaginyl residues in the regulatory HIF-alpha subunits, be...

詳細記述

書誌詳細
主要な著者: Schofield, C, Ratcliffe, P
フォーマット: Journal article
言語:English
出版事項: 2005