Inferring structural variant cancer cell fraction

We present SVclone, a computational method for inferring the cancer cell fraction of structural variant (SV) breakpoints from whole-genome sequencing data. SVclone accurately determines the variant allele frequencies of both SV breakends, then simultaneously estimates the cancer cell fraction and SV...

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Үндсэн зохиолчид: Cmero, M, Yuan, K, Ong, CS, Schröder, J, PCAWG Evolution and Heterogeneity Working Group, Corcoran, NM, Papenfuss, T, Hovens, CM, Markowetz, F, Macintyre, G, PCAWG Consortium
Бусад зохиолчид: Yang, T-P
Формат: Journal article
Хэл сонгох:English
Хэвлэсэн: Springer Nature 2020