Targeting the viral Achilles' heel: recognition of 5'-triphosphate RNA in innate anti-viral defence.

Some RNA virus genomes bear 5'-triphosphates, which can be recognized in the cytoplasm of infected cells by host proteins that mediate anti-viral immunity. Both the innate sensor RIG-I and the interferon-induced IFIT proteins bind to 5'-triphosphate viral RNAs. RIG-I signals for induction...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Rehwinkel, J, Reis e Sousa, C
स्वरूप: Journal article
भाषा:English
प्रकाशित: 2013