Targeting the viral Achilles' heel: recognition of 5'-triphosphate RNA in innate anti-viral defence.
Some RNA virus genomes bear 5'-triphosphates, which can be recognized in the cytoplasm of infected cells by host proteins that mediate anti-viral immunity. Both the innate sensor RIG-I and the interferon-induced IFIT proteins bind to 5'-triphosphate viral RNAs. RIG-I signals for induction...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2013
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| _version_ | 1797100918745858048 |
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| author | Rehwinkel, J Reis e Sousa, C |
| author_facet | Rehwinkel, J Reis e Sousa, C |
| author_sort | Rehwinkel, J |
| collection | OXFORD |
| description | Some RNA virus genomes bear 5'-triphosphates, which can be recognized in the cytoplasm of infected cells by host proteins that mediate anti-viral immunity. Both the innate sensor RIG-I and the interferon-induced IFIT proteins bind to 5'-triphosphate viral RNAs. RIG-I signals for induction of interferons during RNA virus infection while IFITs sequester viral RNAs to exert an anti-viral effect. Notably, the structures of these proteins reveal both similarities and differences, which are suggestive of independent evolution towards ligand binding. 5'-triphosphates, which are absent from most RNAs in the cytosol of uninfected cells, are thus a marker of virus infection that is targeted by the innate immune system for both induction and execution of the anti-viral response. |
| first_indexed | 2024-03-07T05:44:31Z |
| format | Journal article |
| id | oxford-uuid:e6c03ae0-fa8c-45b0-b983-2da4d9d32510 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:44:31Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:e6c03ae0-fa8c-45b0-b983-2da4d9d325102022-03-27T10:33:21ZTargeting the viral Achilles' heel: recognition of 5'-triphosphate RNA in innate anti-viral defence.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e6c03ae0-fa8c-45b0-b983-2da4d9d32510EnglishSymplectic Elements at Oxford2013Rehwinkel, JReis e Sousa, CSome RNA virus genomes bear 5'-triphosphates, which can be recognized in the cytoplasm of infected cells by host proteins that mediate anti-viral immunity. Both the innate sensor RIG-I and the interferon-induced IFIT proteins bind to 5'-triphosphate viral RNAs. RIG-I signals for induction of interferons during RNA virus infection while IFITs sequester viral RNAs to exert an anti-viral effect. Notably, the structures of these proteins reveal both similarities and differences, which are suggestive of independent evolution towards ligand binding. 5'-triphosphates, which are absent from most RNAs in the cytosol of uninfected cells, are thus a marker of virus infection that is targeted by the innate immune system for both induction and execution of the anti-viral response. |
| spellingShingle | Rehwinkel, J Reis e Sousa, C Targeting the viral Achilles' heel: recognition of 5'-triphosphate RNA in innate anti-viral defence. |
| title | Targeting the viral Achilles' heel: recognition of 5'-triphosphate RNA in innate anti-viral defence. |
| title_full | Targeting the viral Achilles' heel: recognition of 5'-triphosphate RNA in innate anti-viral defence. |
| title_fullStr | Targeting the viral Achilles' heel: recognition of 5'-triphosphate RNA in innate anti-viral defence. |
| title_full_unstemmed | Targeting the viral Achilles' heel: recognition of 5'-triphosphate RNA in innate anti-viral defence. |
| title_short | Targeting the viral Achilles' heel: recognition of 5'-triphosphate RNA in innate anti-viral defence. |
| title_sort | targeting the viral achilles heel recognition of 5 triphosphate rna in innate anti viral defence |
| work_keys_str_mv | AT rehwinkelj targetingtheviralachillesheelrecognitionof5triphosphaternaininnateantiviraldefence AT reisesousac targetingtheviralachillesheelrecognitionof5triphosphaternaininnateantiviraldefence |