Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.

Podobne zapisy

• The pVHL-hIF-1 system. A key mediator of oxygen homeostasis.
  od: Maxwell, P, i wsp.
  Wydane: (2001)
• Chemical basis for the selectivity of the von Hippel Lindau tumor suppressor pVHL for prolyl-hydroxylated HIF-1alpha.
  od: Illingworth, C, i wsp.
  Wydane: (2010)
• Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.
  od: Mole, D, i wsp.
  Wydane: (2002)
• Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth.
  od: Keiichi Kondo, i wsp.
  Wydane: (2003-12-01)
• The interaction between the von Hippel-Lindau gene product (pVHL) and hypoxia-inducible factor 1 is disrupted by disease-causing pVHL mutants.
  od: Maher, E, i wsp.
  Wydane: (1999)