Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.

Hypoxia-inducible factor-1 (HIF-1) is a transcriptional complex that controls cellular and systemic homeostatic responses to oxygen availability. HIF-1 alpha is the oxygen-regulated subunit of HIF-1, an alpha beta heterodimeric complex. HIF-1 alpha is stable in hypoxia, but in the presence of oxygen...

תיאור מלא

מידע ביבליוגרפי
Main Authors:	Hon, W, Wilson, M, Harlos, K, Claridge, T, Schofield, C, Pugh, C, Maxwell, P, Ratcliffe, P, Stuart, D, Jones, E
פורמט:	Journal article
שפה:	English
יצא לאור:	2002

פריטים דומים

The pVHL-hIF-1 system. A key mediator of oxygen homeostasis.
מאת: Maxwell, P, et al.
יצא לאור: (2001)

Chemical basis for the selectivity of the von Hippel Lindau tumor suppressor pVHL for prolyl-hydroxylated HIF-1alpha.
מאת: Illingworth, C, et al.
יצא לאור: (2010)

Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.
מאת: Mole, D, et al.
יצא לאור: (2002)

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth.
מאת: Keiichi Kondo, et al.
יצא לאור: (2003-12-01)

The interaction between the von Hippel-Lindau gene product (pVHL) and hypoxia-inducible factor 1 is disrupted by disease-causing pVHL mutants.
מאת: Maher, E, et al.
יצא לאור: (1999)

Effects of point mutations in pVHL on the binding of HIF-1α.
מאת: Domene, C, et al.
יצא לאור: (2012)

Effects of point mutations in pVHL on the binding of HIF-1α
מאת: Domene, C, et al.
יצא לאור: (2012)

Interaction between the von Hippel-Lindau gene product (pVHL) and hypoxia-inducible factor 1 is disrupted by disease causing pVHL mutants
מאת: Clifford, S, et al.
יצא לאור: (1999)

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.
מאת: Clifford, S, et al.
יצא לאור: (2001)

Histone deacetylase inhibitor induced pVHL-independent degradation of HIF-1α and hierarchical quality control of pVHL via chaperone system.
מאת: Jieming Ni, et al.
יצא לאור: (2021-01-01)

The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma.
מאת: Clifford, S, et al.
יצא לאור: (2001)

Inhibition of HIF2α Protein Suppresses pVHL-Driven Tumor Growth.
יצא לאור: (2003-12-01)

COMMD1 Promotes pVHL and O2-Independent Proteolysis of HIF-1alpha via HSP90/70.
מאת: Bart van de Sluis, et al.
יצא לאור: (2009-10-01)

Microtubular stability affects pVHL-mediated regulation of HIF-1alpha via the p38/MAPK pathway in hypoxic cardiomyocytes.
מאת: Miao Teng, et al.
יצא לאור: (2012-01-01)

HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
מאת: Daniel Tarade, et al.
יצא לאור: (2018-08-01)

MDM2 promotes cancer cell survival through regulating the expression of HIF-1α and pVHL in retinoblastoma
מאת: Shouhua Zhang, et al.
יצא לאור: (2023-01-01)

pVHL mediates K63-linked ubiquitination of nCLU.
מאת: Jing Xue, et al.
יצא לאור: (2012-01-01)

Genetic and Epigenetic Mechanisms Deregulate the CRL2pVHL Complex in Hepatocellular Carcinoma
מאת: Brenda C. Minatel, et al.
יצא לאור: (2022-05-01)

The pVHL neglected functions, a tale of hypoxia-dependent and -independent regulations in cancer
מאת: Giovanni Minervini, et al.
יצא לאור: (2020-07-01)

DUB-independent regulation of pVHL by OTUD6B suppresses hepatocellular carcinoma
מאת: Xiaoming Dai, et al.
יצא לאור: (2020-04-01)

Identification and Functional Characterization of pVHL-Dependent Cell Surface Proteins in Renal Cell Carcinoma
מאת: Gunther Boysen, et al.
יצא לאור: (2012-06-01)

Up-regulation of pVHL along with down-regulation of HIF-1α by NDRG2 expression attenuates proliferation and invasion in renal cancer cells.
מאת: Lei Gao, et al.
יצא לאור: (2013-01-01)

Antiangiogenic activity of phthalides-enriched Angelica Sinensis extract by suppressing WSB-1/pVHL/HIF-1α/VEGF signaling in bladder cancer
מאת: Meng-Chuan Chen, et al.
יצא לאור: (2017-07-01)

Retraction. Up-regulation of pVHL along with down-regulation of HIF-1α by NDRG2 expression attenuates proliferation and invasion in renal cancer cells.
יצא לאור: (2014-01-01)

Expression of HIF-1alpha, HIF-2alpha (EPAS1), and their target genes in paraganglioma and pheochromocytoma with VHL and SDH mutations.
מאת: Pollard, P, et al.
יצא לאור: (2006)

The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.
מאת: Talks, K, et al.
יצא לאור: (2000)

Activation of the HIF pathway in cancer.
מאת: Maxwell, P, et al.
יצא לאור: (2001)

Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression.
מאת: Wood, S, et al.
יצא לאור: (1998)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
מאת: Chowdhury, R, et al.
יצא לאור: (2016)

Targeting tumors through the HIF system.
מאת: Ratcliffe, P, et al.
יצא לאור: (2000)

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.
מאת: Elkins, J, et al.
יצא לאור: (2003)

VHL-P138R and VHL-L163R Novel Variants: Mechanisms of VHL Pathogenicity Involving HIF-Dependent and HIF-Independent Actions
מאת: Cecilia Mathó, et al.
יצא לאור: (2022-03-01)

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron.
מאת: Mandriota, S, et al.
יצא לאור: (2002)

Deubiquitylase OTUD6B Governs pVHL Stability in an Enzyme‐Independent Manner and Suppresses Hepatocellular Carcinoma Metastasis
מאת: Xinxin Liu, et al.
יצא לאור: (2020-04-01)

Identification of pVHL as a novel substrate for Aurora-A in clear cell renal cell carcinoma (ccRCC).
מאת: Benedicte Martin, et al.
יצא לאור: (2013-01-01)

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
מאת: Jaakkola, P, et al.
יצא לאור: (2001)

Correction: Identification of pVHL as a Novel Substrate for Aurora-A in Clear Cell Renal Cell Carcinoma (ccRCC)
יצא לאור: (2014-01-01)

Expression of von Hippel–Lindau tumor suppressor protein (pVHL) characteristic of tongue cancer and proliferative lesions in tongue epithelium
מאת: Hisashi Hasegawa, et al.
יצא לאור: (2017-05-01)

Correction: Identification of pVHL as a Novel Substrate for Aurora-A in Clear Cell Renal Cell Carcinoma (ccRCC).
מאת: Benedicte Martin, et al.
יצא לאור: (2014-01-01)

Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling.
מאת: Wykoff, C, et al.
יצא לאור: (2000)