Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.

Hypoxia-inducible factor-1 (HIF-1) is a transcriptional complex that controls cellular and systemic homeostatic responses to oxygen availability. HIF-1 alpha is the oxygen-regulated subunit of HIF-1, an alpha beta heterodimeric complex. HIF-1 alpha is stable in hypoxia, but in the presence of oxygen...

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Dettagli Bibliografici
Autori principali:	Hon, W, Wilson, M, Harlos, K, Claridge, T, Schofield, C, Pugh, C, Maxwell, P, Ratcliffe, P, Stuart, D, Jones, E
Natura:	Journal article
Lingua:	English
Pubblicazione:	2002

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