Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
Hypoxia-inducible factor-1 (HIF-1) is a transcriptional complex that controls cellular and systemic homeostatic responses to oxygen availability. HIF-1 alpha is the oxygen-regulated subunit of HIF-1, an alpha beta heterodimeric complex. HIF-1 alpha is stable in hypoxia, but in the presence of oxygen...
Hlavní autoři: | , , , , , , , , , |
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Médium: | Journal article |
Jazyk: | English |
Vydáno: |
2002
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