Engineered tissue inhibitor of metalloproteinases-3 variants resistant to endocytosis have prolonged chondroprotective activity

Engineered tissue inhibitor of metalloproteinases-3 variants resistant to endocytosis have prolonged chondroprotective activity

Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a central inhibitor of matrix-degrading and sheddase families of metalloproteinases. Extracellular levels of the inhibitor are regulated by the balance between its retention on the extracellular matrix and its endocytic clearance by the scavenger...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Doherty, C, Visse, R, Dinakarpandian, D, Strickland, D, Nagase, H, Troeberg, L
Fformat:	Journal article
Cyhoeddwyd:	American Society for Biochemistry and Molecular Biology 2016

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