Engineered tissue inhibitor of metalloproteinases-3 variants resistant to endocytosis have prolonged chondroprotective activity

Engineered tissue inhibitor of metalloproteinases-3 variants resistant to endocytosis have prolonged chondroprotective activity

Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a central inhibitor of matrix-degrading and sheddase families of metalloproteinases. Extracellular levels of the inhibitor are regulated by the balance between its retention on the extracellular matrix and its endocytic clearance by the scavenger...

Bibliografski detalji
Glavni autori:	Doherty, C, Visse, R, Dinakarpandian, D, Strickland, D, Nagase, H, Troeberg, L
Format:	Journal article
Izdano:	American Society for Biochemistry and Molecular Biology 2016

Slični predmeti

Suramin inhibits osteoarthritic cartilage degradation by increasing extracellular levels of chondroprotective tissue inhibitor of metalloproteinases 3 (TIMP-3)
od: Chanalaris, A, i dr.
Izdano: (2017)

Tissue inhibitors of metalloproteinases: evolution, structure and function.
od: Brew, K, i dr.
Izdano: (2000)

Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry.
od: Visse, R, i dr.
Izdano: (2003)

Designing TIMP (tissue inhibitor of metalloproteinases) variants that are selective metalloproteinase inhibitors.
od: Nagase, H, i dr.
Izdano: (2003)

Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage
od: Yang, CY, i dr.
Izdano: (2020)

Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage
od: C.Y. Yang, i dr.
Izdano: (2020-12-01)

Zymography of metalloproteinases.
od: Troeberg, L, i dr.
Izdano: (2004)

Differential regulation of extracellular tissue inhibitor of metalloproteinases-3 levels by cell membrane-bound and shed low density lipoprotein receptor-related protein 1.
od: Scilabra, S, i dr.
Izdano: (2013)

Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeutics.
od: Nagase, H, i dr.
Izdano: (2002)

LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage.
od: Yamamoto, K, i dr.
Izdano: (2013)

Monitoring metalloproteinase activity using synthetic fluorogenic substrates.
od: Troeberg, L, i dr.
Izdano: (2004)

Structure and function of matrix metalloproteinases and TIMPs.
od: Nagase, H, i dr.
Izdano: (2006)

Protein engineering of the tissue inhibitor of metalloproteinase 1 (TIMP-1) inhibitory domain. In search of selective matrix metalloproteinase inhibitors.
od: Wei, S, i dr.
Izdano: (2003)

Measurement of matrix metalloproteinase activities in the medium of cultured synoviocytes using zymography.
od: Troeberg, L, i dr.
Izdano: (2003)

The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity.
od: Brew, K, i dr.
Izdano: (2010)

Preferential inactivation of tissue inhibitor of metalloproteinases-1 that is bound to the precursor of matrix metalloproteinase 9 (progelatinase B) by human neutrophil elastase.
od: Itoh, Y, i dr.
Izdano: (1995)

The interplay between JNK pathway activation, proteoglycan turnover and endocytosis in chondrocytes
od: Ismail, H, i dr.
Izdano: (2017)

Production of cytokines, vascular endothelial growth factor, matrix metalloproteinases, and tissue inhibitor of metalloproteinases 1 by tenosynovium demonstrates its potential for tendon destruction in rheumatoid arthritis.
od: Jain, A, i dr.
Izdano: (2001)

Identification of the (183)RWTNNFREY(191) region as a critical segment of matrix metalloproteinase 1 for the expression of collagenolytic activity.
od: Chung, L, i dr.
Izdano: (2000)

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) - Physiological roles and structural basis of MMP inhibition by TIMP-1
od: Nagase, H, i dr.
Izdano: (2000)

Steps involved in activation of the complex of pro-matrix metalloproteinase 2 (progelatinase A) and tissue inhibitor of metalloproteinases (TIMP)-2 by 4-aminophenylmercuric acetate.
od: Itoh, Y, i dr.
Izdano: (1995)

Steps involved in activation of the pro-matrix metalloproteinase 9 (progelatinase B)-tissue inhibitor of metalloproteinases-1 complex by 4-aminophenylmercuric acetate and proteinases.
od: Ogata, Y, i dr.
Izdano: (1995)

Evidence base of pharmaconutraceuticals with chondroprotective action
od: O. A. Shavlovskaya, i dr.
Izdano: (2024-04-01)

Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue.
od: Scilabra, S, i dr.
Izdano: (2016)

Phylotranscriptomic analysis uncovers a wealth of tissue inhibitor of metalloproteinases variants in echinoderms
od: Ronald M. Clouse, i dr.
Izdano: (2015-01-01)

Perspectives of chondroprotective therapy of osteoarthritis
od: L L Alekseeva
Izdano: (2003-08-01)

Reactive site mutations in tissue inhibitor of metalloproteinase-3 disrupt inhibition of matrix metalloproteinases but not tumor necrosis factor-alpha-converting enzyme.
od: Wei, S, i dr.
Izdano: (2005)

Structural features of the reprolysin atrolysin C and tissue inhibitors of metalloproteinases (TIMPs) interaction.
od: Pinto, A, i dr.
Izdano: (2006)

Imbalance between matrix metalloproteinase 9 and tissue inhibitor of metalloproteinases 1 expression by tumor cells implicated in liver metastasis from colorectal carcinoma.
od: Ogata, Y, i dr.
Izdano: (2001)

Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2).
od: Kveiborg, M, i dr.
Izdano: (2010)

Matrix metalloproteinases and their inhibitors in human vitreous.
od: De La Paz, MA, i dr.
Izdano: (1998)

Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in renal cell carcinoma
od: Qiao Zhen-kui, i dr.
Izdano: (2013-01-01)

The expression of tissue inhibitor of metalloproteinase 2 (TIMP-2) is required for normal development of zebrafish embryos.
od: Zhang, J, i dr.
Izdano: (2003)

Plasma membrane-bound tissue inhibitor of metalloproteinases (TIMP)-2 specifically inhibits matrix metalloproteinase 2 (gelatinase A) activated on the cell surface.
od: Itoh, Y, i dr.
Izdano: (1998)

MATRIX METALLOPROTEINASES AND TISSUE INHIBITORS OF MATRIX METALLOPROTEINASES DURING PREGNANCY AND DELIVERY
od: Yu. V. Korenovsky, i dr.
Izdano: (2012-09-01)

Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Echinoderms: Structure and Possible Functions
od: Igor Yu. Dolmatov, i dr.
Izdano: (2021-09-01)

Tissue inhibitor of metalloproteinases-3 induces apoptosis in melanoma cells by stabilization of death receptors.
od: Ahonen, M, i dr.
Izdano: (2003)

Tissue inhibitor of metalloproteinases-3 induces apoptosis in melanoma cells by stabilization of death receptors
od: Ahonen, M, i dr.
Izdano: (2002)

Dexamethasone: chondroprotective corticosteroid or catabolic killer?
od: Black, Robert Xavier, i dr.
Izdano: (2020)

CHONDROPROTECTIVE DRUG ALFLUTOP IN THE TREATMENT OF OSTEOARTHRITIS
od: G V Lukina, i dr.
Izdano: (2001-04-01)