Conformational dynamics of M2 helices in KirBac channels: helix flexibility in relation to gating via molecular dynamics simulations.

Conformational dynamics of M2 helices in KirBac channels: helix flexibility in relation to gating via molecular dynamics simulations.

KirBac1.1 and 3.1 are bacterial homologues of mammalian inward rectifier K channels. We have performed extended molecular dynamics simulations (five simulations, each of >20 ns duration) of the transmembrane domain of KirBac in two membrane environments, a palmitoyl oleoyl phosphatidylcholine...

Полное описание

Библиографические подробности
Главные авторы:	Grottesi, A, Domene, C, Hall, B, Sansom, MS
Формат:	Journal article
Язык:	English
Опубликовано:	2005

Схожие документы

Permeation and gating in KirBac: Molecular dynamics simulations
по: Grottesi, A, и др.
Опубликовано: (2004)

Investigating open pore structure: Essential dynamics sampling of motions performed by the inner S6 helix bundle in KirBac.
по: Grottesi, A, и др.
Опубликовано: (2005)

Filter flexibility and distortion in a bacterial inward rectifier K+ channel: simulation studies of KirBac1.1.
по: Domene, C, и др.
Опубликовано: (2004)

Control of KirBac3.1 potassium channel gating at the interface between cytoplasmic domains.
по: Zubcevic, L, и др.
Опубликовано: (2014)

Two different conformational states of the KirBac3.1 potassium channel revealed by electron crystallography.
по: Kuo, A, и др.
Опубликовано: (2005)

Two different conformational states of the KirBac3.1 potassium channel revealed by electron crystallography.
по: Kuo, A, и др.
Опубликовано: (2005)

Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating
по: Bavro, V, и др.
Опубликовано: (2012)

Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating.
по: Bavro, V, и др.
Опубликовано: (2012)

Functional complementation and genetic deletion studies of KirBac channels: activatory mutations highlight gating-sensitive domains.
по: Paynter, J, и др.
Опубликовано: (2010)

Direct visualization of KirBac3.1 potassium channel gating by atomic force microscopy.
по: Jarosławski, S, и др.
Опубликовано: (2007)

Functional complementation and genetic deletion studies of KirBac channels: Activatory mutations highlight gating-sensitive domains
по: Paynter, J, и др.
Опубликовано: (2010)

Crystal structure of the potassium channel KirBac1.1 in the closed state.
по: Kuo, A, и др.
Опубликовано: (2003)

Single-molecule fluorescence studies of KirBac1.1
по: Sadler, E, и др.
Опубликовано: (2015)

Conformational dynamics of the ligand-binding domain of inward rectifier K channels as revealed by molecular dynamics simulations: toward an understanding of Kir channel gating.
по: Haider, S, и др.
Опубликовано: (2005)

Molecular dynamics simulation approaches to K channels: conformational flexibility and physiological function.
по: Grottesi, A, и др.
Опубликовано: (2005)

The open state of KirBac3.1 observed by cryo-electron microscopy
по: Zadek, B, и др.
Опубликовано: (2007)

Molecular dynamics simulation of open and close confirmations of KirBac1.1 in explicit lipid billayer: Structural changes and aromatic localization at lipid/water interface
по: Vemparala, S, и др.
Опубликовано: (2005)

Codon Harmonization of a Kir3.1-KirBac1.3 Chimera for Structural Study Optimization
по: Evan Van Aalst, и др.
Опубликовано: (2020-03-01)

Water Accessibility Refinement of the Extended Structure of KirBac1.1 in the Closed State
по: Reza Amani, и др.
Опубликовано: (2021-11-01)

H bonding at the helix-bundle crossing controls gating in Kir potassium channels.
по: Rapedius, M, и др.
Опубликовано: (2007)

Identification of gain of function mutations in KirBac potassium channels by genetic complementation in K+ auxotrophic strains of E-coli and yeast.
по: Paynter, J, и др.
Опубликовано: (2007)

Control of pH and PIP2 gating in heteromeric Kir4.1/Kir5.1 channels by H-Bonding at the helix-bundle crossing.
по: Rapedius, M, и др.
Опубликовано: (2007)

The intrinsic flexibility of the Kv voltage sensor and its implications for channel gating.
по: Sands, Z, и др.
Опубликовано: (2006)

Conformational dynamics of helix S6 from Shaker potassium channel: simulation studies.
по: Bright, J, и др.
Опубликовано: (2002)

Voltage-gated ion channels.
по: Sands, Z, и др.
Опубликовано: (2005)

Conformational rearrangements during PIP2 gating in Kir channels
по: Rapedius, M, и др.
Опубликовано: (2007)

The role of extra-membranous inter-helical loops in helix-helix interactions.
по: Ulmschneider, M, и др.
Опубликовано: (2005)

Ion channel gating: insights via molecular simulations.
по: Beckstein, O, и др.
Опубликовано: (2003)

Ion channel gates: comparative analysis of energy barriers.
по: Tai, K, и др.
Опубликовано: (2009)

Insights into the structural nature of the transition state in the Kir channel gating pathway.
по: Fowler, P, и др.
Опубликовано: (2014)

Dynamic role of the tether helix in PIP2-dependent gating of a G protein-gated potassium channel
по: Lacin, E, и др.
Опубликовано: (2017)

Helix dynamics in a membrane transport protein: comparative simulations of the glycerol-3-phosphate transporter and its constituent helices.
по: D'Rozario, R, и др.
Опубликовано: (2008)

Molecular dynamics simulations of a K+ channel blocker: Tc1 toxin from Tityus cambridgei.
по: Grottesi, A, и др.
Опубликовано: (2003)

Molecular dynamics simulations of inwardly rectifying (Kir) potassium channels: a comparative study.
по: Haider, S, и др.
Опубликовано: (2007)

Crystal Structure of a Prokaryotic Kir Channel in an Open Conformation
по: Bavro, V, и др.
Опубликовано: (2012)

Proline associated conformational changes in the S6 helix of Kv channels
по: Bright, J, и др.
Опубликовано: (2002)

Molecular dynamics simulations and KcsA channel gating.
по: Shrivastava, I, и др.
Опубликовано: (2002)

Gating at both ends and breathing in the middle: conformational dynamics of TolC.
по: Vaccaro, L, и др.
Опубликовано: (2008)

Filter flexibility in a mammalian K channel: models and simulations of Kir6.2 mutants.
по: Capener, C, и др.
Опубликовано: (2003)

Proline-induced hinges in transmembrane helices: possible roles in ion channel gating.
по: Tieleman, D, и др.
Опубликовано: (2001)