Post-translational insertion of boron in proteins to probe and modulate function

Boron is absent in proteins, yet is a micronutrient. It possesses unique bonding that could expand biological function including modes of Lewis acidity not available to typical elements of life. Here we show that post-translational Cβ–Bγ bond formation provides mild, direct, site-selective access to...

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Autors principals: Mollner, TA, Isenegger, PG, Josephson, B, Buchanan, C, Lercher, L, Oehlrich, D, Hansen, DF, Mohammed, S, Baldwin, AJ, Gouverneur, V, Davis, BG
Format: Journal article
Idioma:English
Publicat: Springer Nature 2021