Lysine-241 has a role in coupling 2OG turnover with substrate oxidation during KDM4-catalysed histone demethylation

The JmjC histone demethylases (KDMs) play important roles in modulating histone methylation states and have the potential to be regulated by oxygen availability. Lys-241 of the KDM4 subfamily is proposed to be important in oxygen binding by KDM4A. We report evidence that, although K241 is unlikely t...

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Bibliographic Details
Main Authors: Hancock, R, Abboud, M, Smart, T, Flashman, E, Kawamura, A, Schofield, C, Hopkinson, R
Format: Journal article
Language:English
Published: Wiley‐VCH Verlag 2018