Lysine-241 has a role in coupling 2OG turnover with substrate oxidation during KDM4-catalysed histone demethylation
The JmjC histone demethylases (KDMs) play important roles in modulating histone methylation states and have the potential to be regulated by oxygen availability. Lys-241 of the KDM4 subfamily is proposed to be important in oxygen binding by KDM4A. We report evidence that, although K241 is unlikely t...
| Main Authors: | , , , , , , |
|---|---|
| 格式: | Journal article |
| 语言: | English |
| 出版: |
Wiley‐VCH Verlag
2018
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