Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality

Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality

Enhancing thermogenic brown adipose tissue (BAT) function is a promising therapeutic strategy for metabolic disease. However, predominantly thermoneutral modern human living conditions deactivate BAT. We demonstrate that selective adipocyte deficiency of the oxygen-sensor HIF-prolyl hydroxylase (PHD...

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Bibliographic Details
Main Authors: Wang, R, Gomez Salazar, M, Pruñonosa Cervera, I, Coutts, A, French, K, Pinto, MM, Gohlke, S, García-Martín, R, Blüher, M, Schofield, CJ, Kourtzelis, I, Stimson, RH, Bénézech, C, Christian, M, Schulz, TJ, Gudmundsson, EF, Jennings, LL, Gudnason, VG, Chavakis, T, Morton, NM, Emilsson, V, Michailidou, Z
Format: Journal article
Language:English
Published: Nature Research 2024

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