Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions.

The development of a highly effective vaccine remains a key strategic goal to aid the control and eventual eradication of Plasmodium falciparum malaria. In recent years, the reticulocyte-binding protein homolog 5 (RH5) has emerged as the most promising blood-stage P. falciparum candidate antigen to...

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Main Authors: Payne, RO, Silk, SE, Elias, SC, Miura, K, Diouf, A, Galaway, F, de Graaf, H, Brendish, NJ, Poulton, ID, Griffiths, OJ, Edwards, NJ, Jin, J, Labbé, GM, Alanine, DGW, Siani, L, Di Marco, S, Roberts, R, Green, N, Berrie, EE, Ishizuka, AS, Nielsen, CN, Bardelli, M, Partey, FD, Ofori, MF, Barfod, L, Wambua, J, Murungi, LM, Osier, FH, Biswas, S, McCarthy, JS, Minassian, AM, Ashfield, R, Viebig, NK, Nugent, FL, Douglas, AD, Vekemans, J, Wright, GJ, Faust, SN, Hill, AV, Long, CA, Lawrie, AM, Draper, SJ
Format: Journal article
Language:English
Published: American Society for Clinical Investigation 2017