Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2.

Oxygen-dependent prolyl hydroxylation of hypoxia-inducible factor (HIF) by a set of closely related prolyl hydroxylase domain enzymes (PHD1, 2 and 3) regulates a range of transcriptional responses to hypoxia. This raises important questions about the role of these oxygen-sensing enzymes in integrati...

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Bibliographic Details
Main Authors:	Bishop, T, Talbot, N, Turner, P, Nicholls, L, Pascual, A, Hodson, E, Douglas, G, Fielding, J, Smith, T, Demetriades, M, Schofield, C, Robbins, P, Pugh, C, Buckler, K, Ratcliffe, P
Format:	Journal article
Language:	English
Published:	2013

Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2.

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