Functionalized bicyclo[3.3.0]octanes by enantioselective transannular desymmetrization.

[figure: see text] Enantioselective alpha-deprotonation-rearrangement of achiral substituted cyclooctene oxides 7, 17, and 18 using organolithiums in the presence of (-)-sparteine (3) or (-)-alpha-isosparteine (4) gives the functionalized bicyclo[3.3.0]octan-2-ols 8, 19, and 20 in 56-72% yields and...

Full description

Bibliographic Details
Main Authors: Hodgson, D, Cameron, I
Format: Journal article
Language:English
Published: 2001