Nude mutation influences limb skeletal muscle development.
The nude mouse lacks functional T cells and other skin defects due to the absence of Foxn1 transcription factor. The mdx mouse bred onto a nude background (Foxn1-/-), to generate mdx nu/nu, serves as a valuable model for the use in muscle cell transplantation or gene therapy studies, to avoid a detr...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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